Searchable abstracts of presentations at key conferences in endocrinology

ea0070oc9.5 | Reproductive and Developmental Endocrinology | ECE2020

Genetic dissection of spermatogenic arrest through whole exome analysis: Clinical implications for the management of azoospermic men

Riera_Escamilla Antoni , Moreno-Mendoza Daniel , Holleman Kaylee , Casamonti Elena , Cioppi Francesca , Pietroforte Sara , Ruiz-Castané Eduard , Baarends Willy , Krausz Csilla

Background: Non-obstructive azoospermia affects about 1% of men and has a multifactorial etiology with heterogeneous testicular histology. Pure spermatogenic maturation arrest (MA) is a relatively rare NOA phenotype but its clinical relevance is high, since patients affected by MA should not undergo invasive testis surgery. A clear-cut distinction between MA and other spermatogenic disturbances leading to azoospermia is not possible with the currently available clinical tools....